Dr. Mohanad Diab
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Targeted Therapy

Precision medicine that targets specific cancer cell mutations for personalized treatment.

Targeted Therapy at Mediclinic Abu Dhabi


Targeted therapy represents the frontier of precision oncology. Unlike traditional chemotherapy, targeted drugs attack specific molecular targets on cancer cells while sparing healthy tissue.


How Targeted Therapy Works


Cancer cells often have specific genetic mutations that drive their growth. Targeted therapy drugs are designed to:


  • Block growth signals: that cancer cells depend on
  • Prevent new blood vessel formation: (angiogenesis inhibitors)
  • Deliver toxic substances directly: to cancer cells
  • Trigger immune destruction: of cancer cells

    • Common Targeted Therapies


  • HER2-targeted therapy: For HER2-positive breast and gastric cancers
  • EGFR inhibitors: For certain lung cancers
  • BRAF inhibitors: For melanoma and other cancers
  • CDK4/6 inhibitors: For hormone receptor-positive breast cancer
  • PARP inhibitors: For BRCA-mutated cancers

    • The Role of Molecular Profiling


    Before starting targeted therapy, Dr. Diab orders comprehensive molecular profiling to identify:


  • Specific gene mutations (EGFR, ALK, ROS1, BRAF, etc.)
  • Protein expression levels (HER2, PD-L1)
  • Microsatellite instability (MSI)
  • Tumor mutational burden (TMB)

    • This ensures every patient receives the most effective targeted drug for their specific cancer.


    Benefits of Targeted Therapy


  • More precise than traditional chemotherapy
  • Often fewer side effects
  • Can be combined with other treatments
  • Available as oral medications (pills)
  • Effective even in advanced stages

    • Consult Dr. Mohanad Diab to learn if targeted therapy is appropriate for your cancer type.

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